5AR4
RIP2 Kinase Catalytic Domain (1 - 310) complex with SB-203580
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 | polymer | 326 | 37606.0 | 2 | UniProt (O43353) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | CARD-CONTAINING INTERLEUKIN-1 BETA-CONVERTING ENZYME-ASSOCIATED KINASE, CARD-CONTAINING IL-1 BETA ICE-KINASE, RIP-LIKE-INTERACTING CLARP KINASE, RECEPTOR-INTERACTING PROTEIN 2, RIP-2, TYROSINE-PROTEIN KINASE RIPK2 |
| 2 | C, D (A, B) | 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE | non-polymer | 377.4 | 2 | Chemie (SB2) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 310 (UniProt: O43353)
| PDB | External Database | Details |
|---|---|---|
| Met -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Tyr -13 | - | expression tag |
| Lys -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Lys -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75212.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 754.9 | |
| All* | Total formula weight | 75966.8 |
