5AQS
Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | HEAT SHOCK COGNATE 71 KDA PROTEIN | polymer | 386 | 42407.0 | 2 | UniProt (P11142) Pfam (PF00012) | HOMO SAPIENS (HUMAN) | |
| 2 | B, D (B, D) | BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 | polymer | 118 | 13511.6 | 2 | UniProt (Q99933) Pfam (PF02179) | HOMO SAPIENS (HUMAN) | |
| 3 | E, K (A, C) | ISOQUINOLIN-1-AMINE | non-polymer | 144.2 | 2 | Chemie (1SQ) PubChem (73742) | |||
| 4 | F, G, H, I, J... (A, B, C) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) PubChem (753) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 496 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 381 (UniProt: P11142)
B, D: 151 - 263 (UniProt: Q99933)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 146 | - | expression tag |
| Pro 147 | - | expression tag |
| Leu 148 | - | expression tag |
| Gly 149 | - | expression tag |
| Ser 150 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 111837.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1025.1 | |
| All* | Total formula weight | 112862.2 |
