5AQM
Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | HEAT SHOCK COGNATE 71 KDA PROTEIN | polymer | 386 | 42467.1 | 2 | UniProt (P11142) Pfam (PF00012) In PDB | HOMO SAPIENS (HUMAN) | HEAT SHOCK 70 KDA PROTEIN 8, LIPOPOLYSACCHARIDE-ASSOCIATED PROTEIN 1, LAP-1, LPS-ASSOCIATED PROTEIN 1 |
2 | B, D | BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 | polymer | 118 | 13511.6 | 2 | UniProt (Q99933) Pfam (PF02179) In PDB | HOMO SAPIENS (HUMAN) | BAG-1, BCL-2-ASSOCIATED ATHANOGENE 1 |
3 | A, C | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 4 | Chemie (TRS) | |||
4 | A, B, C, D | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
5 | water | water | 18.0 | 1017 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 381 (UniProt: P11142)
B, D: 151 - 263 (UniProt: Q99933)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Leu -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Phe 275 | Ser 275 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 146 | - | expression tag |
Pro 147 | - | expression tag |
Leu 148 | - | expression tag |
Gly 149 | - | expression tag |
Ser 150 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 111957.3 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1041.1 | |
All* | Total formula weight | 112998.4 |