5AO2
Crystal structure of human SAMHD1 (amino acid residues 115-583) R164A variant bound to dGTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 | polymer | 491 | 56798.0 | 4 | UniProt (Q9Y3Z3) Pfam (PF01966) | HOMO SAPIENS (HUMAN) | DNTPASE, DENDRITIC CELL-DERIVED IFNG-INDUCED PROTEIN, DCIP, MONOCYTE PROTEIN 5, MOP-5, SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN 1, SAMHD1 |
| 2 | E, G, I, L (A, B, C, D) | FE (III) ION | non-polymer | 55.8 | 4 | Chemie (FE) | |||
| 3 | F, H, J, K (A, B, C) | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (DGT) | |||
| 4 | M, N, O (A, B, C) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 115 - 583 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Met 93 | - | expression tag |
| Ala 94 | - | expression tag |
| Ser 95 | - | expression tag |
| Trp 96 | - | expression tag |
| Ser 97 | - | expression tag |
| His 98 | - | expression tag |
| Pro 99 | - | expression tag |
| Gln 100 | - | expression tag |
| Phe 101 | - | expression tag |
| Glu 102 | - | expression tag |
| Lys 103 | - | expression tag |
| Gly 104 | - | expression tag |
| Ala 105 | - | expression tag |
| Leu 106 | - | expression tag |
| Glu 107 | - | expression tag |
| Val 108 | - | expression tag |
| Leu 109 | - | expression tag |
| Phe 110 | - | expression tag |
| Gln 111 | - | expression tag |
| Gly 112 | - | expression tag |
| Pro 113 | - | expression tag |
| Gly 114 | - | expression tag |
| Ala 164 | Arg 164 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 227192.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2252.1 | |
| All* | Total formula weight | 229444.1 |
