5ANS
Potent and selective inhibitors of MTH1 probe its role in cancer cell survival
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE | polymer | 175 | 20011.6 | 1 | UniProt (P36639) Pfam (PF00293) In PDB | HOMO SAPIENS (HUMAN) | 2-HYDROXY-DATP DIPHOSPHATASE, 8-OXO-DGTPASE, NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 1, NUDIX MOTIF 1 |
2 | A | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol | non-polymer | 314.4 | 1 | Chemie (RX8) | |||
3 | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A: 1 - 156 (UniProt: P36639)
PDB | External Database | Details |
---|---|---|
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 20011.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 314.4 | |
All* | Total formula weight | 20326.0 |