5AJQ
Human LOK (STK10) in complex with Bosutinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | SERINE/THREONINE-PROTEIN KINASE 10 | polymer | 295 | 33436.6 | 2 | UniProt (O94804) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | STK10, LYMPHOCYTE-ORIENTED KINASE |
| 2 | C, F (A, B) | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | non-polymer | 530.4 | 2 | Chemie (DB8) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 313 (UniProt: O94804)
| PDB | External Database | Details |
|---|---|---|
| Ser 19 | - | expression tag |
| Met 20 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66873.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1158.4 | |
| All* | Total formula weight | 68031.6 |
