5AJN
Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-Cys13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 | polymer | 571 | 64824.7 | 1 | UniProt (Q10471) Pfam (PF00535) Pfam (PF00652) | HOMO SAPIENS (HUMAN) | POLYPEPTIDE GALNAC TRANSFERASE 2, GALNAC-T2, PP-GANTASE 2, PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE 2, |
| 2 | B (P) | MUCIN | polymer | 16 | 1477.6 | 1 | UniProt (Q14886) UniProt (by SIFTS) (P98088) | HOMO SAPIENS (HUMAN) | MUC5AC |
| 3 | C, CA, D, E, F... (A) | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 4 | BA, N, O, P, Q... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 5 | AA (A) | 2-acetamido-2-deoxy-alpha-D-galactopyranose | non-polymer | 221.2 | 1 | Chemie (A2G) | |||
| 6 | DA, EA (A, P) | water | water | 18.0 | 555 | Chemie (HOH) |
Sequence modifications
A: 1 - 571 (UniProt: Q10471)
P: 1 - 15 (UniProt: Q14886)
| PDB | External Database | Details |
|---|---|---|
| Asp 516 | Asn 516 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 16 | - | expression tag |
| Cys 13 | Thr 77 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66302.3 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 2242.9 | |
| All* | Total formula weight | 68545.2 |
