5AJN

Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-Cys13

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2	polymer	571	64824.7	1	UniProt (Q10471) Pfam (PF00535) Pfam (PF00652) In PDB	HOMO SAPIENS (HUMAN)	POLYPEPTIDE GALNAC TRANSFERASE 2, GALNAC-T2, PP-GANTASE 2, PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE 2,
2	P	MUCIN	polymer	16	1477.6	1	UniProt (Q14886) UniProt (by SIFTS) (P98088) In PDB	HOMO SAPIENS (HUMAN)	MUC5AC
3	A	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	14	Chemie (EDO)
5	A	2-acetamido-2-deoxy-alpha-D-galactopyranose	non-polymer		221.2	1	Chemie (A2G)
6		water	water		18.0	555	Chemie (HOH)

Sequence modifications

A: 1 - 571 (UniProt: Q10471)

PDB	External Database	Details
Asp 516	Asn 516	engineered mutation

P: 1 - 15 (UniProt: Q14886)

PDB	External Database	Details
Ala 16	-	expression tag
Cys 13	Thr 77	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66302.3
Non-Polymers*	Number of molecules	27
	Total formula weight	2242.9
All*	Total formula weight	68545.2

*Water molecules are not included.