5AEJ

Crystal structure of human Gremlin-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	GREMLIN-1	polymer	152	17535.2	4	UniProt (O60565) Pfam (PF03045)	HOMO SAPIENS (HUMAN)	CELL PROLIFERATION-INDUCING GENE 2 PROTEIN, CYSTEINE KNOT SUPERFAMILY 1, BMP ANTAGONIST 1, DAN DOMAIN FAMILY MEMBER 2, DOWN-REGULATED IN MOS-TRANSFORMED CELLS PROTEIN, INCREASED IN HIGH GLUCOSE PROTEIN 2, IHG-2
2	E, F (A, D)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	G, H, I, J (A, B, C, D)	water	water		18.0	283	Chemie (HOH)

Sequence modifications

A, B, C, D: 72 - 184 (UniProt: O60565)

PDB	External Database	Details
Met 33	-	expression tag
Asn 34	-	expression tag
Thr 35	-	expression tag
Ile 36	-	expression tag
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
Asn 43	-	expression tag
Thr 44	-	expression tag
Ser 45	-	expression tag
Gly 46	-	expression tag
Ser 47	-	expression tag
Gly 48	-	expression tag
Gly 49	-	expression tag
Gly 50	-	expression tag
Gly 51	-	expression tag
Gly 52	-	expression tag
Arg 53	-	expression tag
Leu 54	-	expression tag
Val 55	-	expression tag
Pro 56	-	expression tag
Arg 57	-	expression tag
Gly 58	-	expression tag
Ser 59	-	expression tag
Met 60	-	expression tag
Ser 61	-	expression tag
Glu 62	-	expression tag
Asn 63	-	expression tag
Leu 64	-	expression tag
Tyr 65	-	expression tag
Phe 66	-	expression tag
Gln 67	-	expression tag
Gly 68	-	expression tag
Ser 69	-	expression tag
Met 70	-	expression tag
Ser 71	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	70140.6
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	70332.7

*Water molecules are not included.