5ADE
Structure of rat neuronal nitric oxide synthase M336V D597N mutant heme domain in complex with 7-((4-Chloro-3-((methylamino)methyl) phenoxy)methyl)quinolin-2-amine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | NITRIC OXIDE SYNTHASE, BRAIN | polymer | 422 | 48779.5 | 2 | UniProt (P29476) Pfam (PF02898) In PDB | RATTUS NORVEGICUS (NORWAY RAT) | BNOS, CONSTITUTIVE NOS, NC-NOS, NOS TYPE I, NEURONAL NOS, N-NOS, NNOS, PEPTIDYL-CYSTEINE S-NITROSYLASE NOS1, NEURONAL NITRIC OXIDE SYNTHASE |
2 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
3 | A, B | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
4 | A, B | 7-[[4-chloranyl-3-(methylaminomethyl)phenoxy]methyl]quinolin-2-amine | non-polymer | 327.8 | 2 | Chemie (XEB) | |||
5 | A, B | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
6 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
7 | water | water | 18.0 | 236 | Chemie (HOH) |
Sequence modifications
A, B: 297 - 718 (UniProt: P29476)
PDB | External Database | Details |
---|---|---|
Val 336 | Met 336 | engineered mutation |
Asn 597 | Asp 597 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 97559.0 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2554.6 | |
All* | Total formula weight | 100113.5 |