5AD3
Bivalent binding to BET bromodomains
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | BROMODOMAIN-CONTAINING PROTEIN 4 | polymer | 127 | 15099.4 | 2 | UniProt (O60885) Pfam (PF00439) In PDB | HOMO SAPIENS (HUMAN) | PROTEIN HUNK1, BRD4 |
| 2 | B | 3-methoxy-N-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-N-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine | non-polymer | 530.6 | 1 | Chemie (K6K) | |||
| 3 | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A, B: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30198.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 530.6 | |
| All* | Total formula weight | 30729.3 |
