5ACO
Cryo-EM structure of PGT128 Fab in complex with BG505 SOSIP.664 Env trimer
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D (A, C, D) | HIV-1 ENVELOPE GLYCOPROTEIN | polymer | 476 | 53278.3 | 3 | UniProt (Q2N0S6) Pfam (PF00516) | HUMAN IMMUNODEFICIENCY VIRUS 1 | |
| 2 | B, E, F (B, E, F) | HIV-1 ENVELOPE GLYCOPROTEIN | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) | HUMAN IMMUNODEFICIENCY VIRUS 1 | |
| 3 | G, H, I (G, H, I) | PGT128 FAB | polymer | 239 | 25580.7 | 3 | HOMO SAPIENS (HUMAN) | ||
| 4 | J, K, L (J, K, L) | PGT128 FAB | polymer | 211 | 22224.6 | 3 | HOMO SAPIENS (HUMAN) | ||
| 5 | AB, DA, FA, FB, GA... (0, d, f, 5, g...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 18 | In PDB GlyTouCan (G15407YE) | |||
| 6 | AA, BA, CA, EA, EB... (a, b, c, e, 4...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 21 | In PDB GlyTouCan (G42666HT) | |||
| 7 | CB, JA, MA, S, V... (2, j, m, S, V...) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 6 | In PDB GlyTouCan (G07617FP) | |||
| 8 | BB, LA, U (1, l, U) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 9 | DB, NA, W (3, n, W) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 3 | In PDB GlyTouCan (G40702WU) | |||
| 10 | LB, MB, NB, OB, PB... (A, B, C, D, E...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) |
Sequence modifications
A, C, D: 31 - 508 (UniProt: Q2N0S6)
B, E, F: 512 - 664 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | engineered mutation |
| Cys 605 | Thr 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 354690.2 | |
| Branched | Number of molecules | 51 |
| Total formula weight | 34777.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1990.9 | |
| All* | Total formula weight | 391458.9 |
