5ACC
A Novel Oral Selective Estrogen Receptor Down-regulator, AZD9496, drives Tumour Growth Inhibition in Estrogen Receptor positive and ESR1 Mutant Models
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ESTROGEN RECEPTOR | polymer | 248 | 28242.0 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | HOMO SAPIENS (HUMAN) | ER, ER-ALPHA, ESTRADIOL RECEPTOR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP A MEMBER 1, ESTROGEN RECEPTOR ALPHA |
| 2 | A | (E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2- METHYLPROPYL)-3-METHYL-2,3,4,9-TETRAHYDRO-1H-PYRIDO(3,4-B)INDOL-1-YL)PHENYL)ACRYLIC ACID | non-polymer | 442.5 | 1 | Chemie (KE9) | |||
| 3 | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 307 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28242.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 442.5 | |
| All* | Total formula weight | 28684.5 |
