5AB0

Crystal structure of aminopeptidase ERAP2 with ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	ENDOPLASMATIC RETICULUM AMINOPEPTIDASE 2	polymer	967	111563.4	2	UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB	HOMO SAPIENS (HUMAN)	LEUKOCYTE-DERIVED ARGININE AMINOPEPTIDASE, L-RAP
2	E, F	DG025	polymer	10	1313.5	2		SYNTHETIC CONSTRUCT
3	B, H, J	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
4	D, G	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	I	beta-D-mannopyranose-(1-4)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G93777VW)
6	A, C	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	A, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	10	Chemie (NAG)
8	C, A	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
9	A	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
10		water	water		18.0	403	Chemie (HOH)

Sequence modifications

A, C: 1 - 960 (UniProt: Q6P179)

PDB	External Database	Details
Arg 961	-	expression tag
His 962	-	expression tag
His 963	-	expression tag
His 964	-	expression tag
His 965	-	expression tag
His 966	-	expression tag
His 967	-	expression tag
Asn 392	Lys 392	variant

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	225753.9
Branched	Number of molecules	6
	Total formula weight	3357.1
Non-Polymers*	Number of molecules	17
	Total formula weight	2786.4
All*	Total formula weight	231897.4

*Water molecules are not included.