5AAE
Aurora A kinase bound to an imidazopyridine inhibitor (14d)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | AURORA KINASE A | polymer | 285 | 32884.7 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | AURORA 2, AURORA/IPL1-RELATED KINASE 1, ARK-1, AURORA-RELATED KINASE 1, HARK1, BREAST TUMOR-AMPLIFIED KINASE, SERINE/ THREONINE-PROTEIN KINASE 15, SERINE/THREONINE-PROTEIN KINASE 6, SERINE/ THREONINE-PROTEIN KINASE AURORA-A, AURORA A |
2 | A | 3-((4-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)-1H-pyrazol-1-yl)methyl)-5-methylisoxazole | non-polymer | 408.8 | 1 | Chemie (7HD) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
PDB | External Database | Details |
---|---|---|
Gly 119 | - | expression tag |
Ala 120 | - | expression tag |
Met 121 | - | expression tag |
Ala 290 | Cys 290 | engineered mutation |
Ala 393 | Cys 393 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32884.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 408.8 | |
All* | Total formula weight | 33293.5 |