5A86
Structure of pregnane X receptor in complex with a Sphingosine 1- Phosphate Receptor 1 Antagonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 | polymer | 314 | 36136.7 | 2 | UniProt (O75469) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | ORPHAN NUCLEAR RECEPTOR PAR1, ORPHAN NUCLEAR RECEPTOR PXR, PREGNANE X RECEPTOR, STEROID AND XENOBIOTIC RECEPTOR, SXR, STEROID RECEPTOR COACTIVATOR 1 |
| 2 | C, D (C, D) | NUCLEAR RECEPTOR COACTIVATOR 1 | polymer | 17 | 2022.3 | 2 | UniProt (Q15788) | HOMO SAPIENS (HUMAN) | NCOA-1, CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 74, BHLHE74, PROTEIN HIN-2, RIP160, RENAL CARCINOMA ANTIGEN NY-REN-52, STEROID RECEPTOR COACTIVATOR 1, SRC-1, STEROID RECEPTOR COACTIVATOR 1 |
| 3 | E, F (A, B) | 4-chloro-N-[(1R)-1-[1-ethyl-6-(trifluoromethyl)benzimidazol-2-yl]ethyl]benzenesulfonamide | non-polymer | 431.9 | 2 | Chemie (D7E) | |||
| 4 | G, H, I, J, K... (A, B, C, D) | water | water | 18.0 | 301 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 432 (UniProt: O75469)
| PDB | External Database | Details |
|---|---|---|
| Met 119 | - | expression tag |
| Lys 120 | - | expression tag |
| Lys 121 | - | expression tag |
| Gly 122 | - | expression tag |
| His 123 | - | expression tag |
| His 124 | - | expression tag |
| His 125 | - | expression tag |
| His 126 | - | expression tag |
| His 127 | - | expression tag |
| His 128 | - | expression tag |
| Gly 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 76318.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 863.7 | |
| All* | Total formula weight | 77181.9 |
