5A5S
NN-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-5-methoxypyridin-3-yl-3- methyl-8-piperidin-4-ylamino-1,2-dihydro-1,7-naphthyridin-2-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BROMODOMAIN-CONTAINING PROTEIN 4 | polymer | 127 | 15100.4 | 1 | UniProt (O60885) Pfam (PF00439) | HOMO SAPIENS (HUMAN) | PROTEIN HUNK1, HUMAN BRD4 |
| 2 | B (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | C (A) | 5-(5-methoxypyridin-3-yl)-3-methyl-8-[(piperidin-4-yl)amino]-1,2-dihydro-1,7-naphthyridin-2-one | non-polymer | 365.4 | 1 | Chemie (NP8) | |||
| 4 | D (A) | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence modifications
A: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
| Lys 78 | Gln 78 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15100.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 427.5 | |
| All* | Total formula weight | 15527.9 |
