5A5H

The crystal structure of the GST-like domains complex of EPRS C92SC105SC123S mutant-AIMP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE	polymer	175	19404.5	4	UniProt (P07814) Pfam (PF21972)	HOMO SAPIENS (HUMAN)	BIFUNCTIONAL AMINOACYL-TRNA SYNTHETASE, CELL PROLIFERATION- INDUCING GENE 32 PROTEIN, GLUTAMATYL-PROLYL-TRNA SYNTHETASE, GLUTAMYL-TRNA SYNTHETASE, GLURS, PROLYL-TRNA SYNTHETASE, GLUTAMYL- PROLYL-TRNA SYNTHETASE
2	B, D, F, H (B, D, F, H)	AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONA L PROTEIN 2	polymer	240	26790.9	4	UniProt (Q13155) Pfam (PF18569) Pfam (PF00043)	HOMO SAPIENS (HUMAN)	MULTISYNTHASE COMPLEX AUXILIARY COMPONENT P38, PROTEIN JTV- 1
3	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	409	Chemie (HOH)

Sequence modifications

A, C, E, G: 1 - 175 (UniProt: P07814)

PDB	External Database	Details
Ser 92	Cys 92	engineered mutation
Ser 105	Cys 105	engineered mutation
Ser 123	Cys 123	engineered mutation

B, D, F, H: 90 - 320 (UniProt: Q13155)

PDB	External Database	Details
Met 89	-	expression tag
Leu 321	-	expression tag
Glu 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	184781.6
All*	Total formula weight	184781.6

*Water molecules are not included.