5A31
Structure of the human APC-Cdh1-Hsl1-UbcH10 complex.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 | polymer | 1441 | 159616.5 | 1 | Pfam (PF12859) Pfam (PF20518) Pfam (PF21282) Pfam (PF18122) UniProt (by SIFTS) (Q9H1A4) In PDB | HOMO SAPIENS (HUMAN) | APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR, TESTIS-SPECIFIC GENE 24 PROTEIN |
2 | B | ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 | polymer | 84 | 9866.7 | 1 | UniProt (Q9NYG5) Pfam (PF12861) In PDB | HOMO SAPIENS (HUMAN) | APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA-ASSOC IATED RING FINGER PROTEIN |
3 | C, P | CELL DIVISION CYCLE PROTEIN 23 HOMOLOG | polymer | 597 | 68905.0 | 2 | UniProt (Q9UJX2) Pfam (PF04049) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME SUBUNIT 8, THE ANAPHASE-PROMOTING COMPLEX |
4 | D | ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 | polymer | 121 | 14302.7 | 1 | UniProt (P60006) Pfam (PF15243) In PDB | HOMO SAPIENS (HUMAN) | APC15 |
5 | E | ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 | polymer | 110 | 11678.0 | 1 | UniProt (Q96DE5) Pfam (PF17256) In PDB | HOMO SAPIENS (HUMAN) | APC16, CYCLOSOME SUBUNIT 16 |
6 | F, H | ANAPHASE-PROMOTING COMPLEX SUBUNIT 3 | polymer | 824 | 92005.1 | 2 | UniProt (P30260) Pfam (PF12895) Pfam (PF00515) In PDB | HOMO SAPIENS (HUMAN) | CELL DIVISION CYCLE PROTEIN 27 HOMOLOG, APC3, CDC27 HOMOLOG, CDC27HS, H-NUC |
7 | G, W | ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 | polymer | 85 | 9794.0 | 2 | UniProt (Q8NHZ8) Pfam (PF10471) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG |
8 | I | ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 | polymer | 808 | 92205.2 | 1 | UniProt (Q9UJX5) Pfam (PF12894) Pfam (PF12896) In PDB | HOMO SAPIENS (HUMAN) | APC4, CYCLOSOME SUBUNIT 4 |
9 | J | ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 | polymer | 620 | 71631.5 | 1 | UniProt (Q13042) Pfam (PF12895) Pfam (PF13424) In PDB | HOMO SAPIENS (HUMAN) | CELL DIVISION CYCLE PROTEIN 16 HOMOLOG, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6 |
10 | K | ANAPHASE-PROMOTING COMPLEX SUBUNIT 6 | polymer | 620 | 71806.7 | 1 | UniProt (Q13042) Pfam (PF12895) Pfam (PF13424) In PDB | HOMO SAPIENS (HUMAN) | CELL DIVISION CYCLE PROTEIN 16 HOMOLOG, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6 |
11 | L | ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 | polymer | 185 | 21282.1 | 1 | UniProt (Q9UM13) Pfam (PF03256) In PDB | HOMO SAPIENS (HUMAN) | APC10, CYCLOSOME SUBUNIT 10 |
12 | M | ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 | polymer | 74 | 8528.3 | 1 | UniProt (Q2NKV2) Pfam (PF05839) UniProt (by SIFTS) (Q9BS18) In PDB | HOMO SAPIENS (HUMAN) | APC13, CYCLOSOME SUBUNIT 13 |
13 | N | ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 | polymer | 703 | 79116.5 | 1 | Pfam (PF00888) Pfam (PF08672) UniProt (by SIFTS) (Q9UJX6) In PDB | HOMO SAPIENS (HUMAN) | APC2, CYCLOSOME SUBUNIT 2 |
14 | O | ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 | polymer | 755 | 85087.5 | 1 | UniProt (Q9UJX4) Pfam (PF21371) Pfam (PF12862) In PDB | HOMO SAPIENS (HUMAN) | APC5, CYCLOSOME SUBUNIT 5 |
15 | Q | FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 S | polymer | 162 | 17793.4 | 1 | Pfam (PF00179) UniProt (by SIFTS) (O00762) In PDB | HOMO SAPIENS (HUMAN) | (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME C, E2 UBIQUITIN-CONJUGATING ENZYME C, UBCH10, UBIQUITIN CARRIER PROTEIN C, UBIQUITIN-PROTEIN LIGASE C, UBIQUITIN CARRIER PROTEIN S, E2 UBIQUITIN-CONJUGATING ENZYME S, UBIQUITIN-CONJUGATING ENZYME E2-24 KDA, E2-EPF, UBIQUITIN-CONJUGATING ENZYME E2-EPF5, UBIQUITIN-PROTEIN LIGASE S |
16 | R | THE ANAPHASE-PROMOTING COMPLEX CHAIN R | polymer | 386 | 42944.5 | 1 | Pfam (PF00400) UniProt (by SIFTS) (P53197) In PDB | HOMO SAPIENS (HUMAN) | |
17 | T | THE ANAPHASE-PROMOTING COMPLEX CHAIN T | polymer | 21 | 1876.3 | 1 | HOMO SAPIENS (HUMAN) | ||
18 | U | THE ANAPHASE-PROMOTING COMPLEX CHAIN U | polymer | 24 | 2060.5 | 1 | HOMO SAPIENS (HUMAN) | ||
19 | V | THE ANAPHASE-PROMOTING COMPLEX CHAIN V | polymer | 13 | 1421.7 | 1 | HOMO SAPIENS (HUMAN) | ||
20 | X, Y | ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 | polymer | 599 | 66832.2 | 2 | UniProt (Q9UJX3) Pfam (PF13181) Pfam (PF13432) In PDB | HOMO SAPIENS (HUMAN) | APC7, CYCLOSOME SUBUNIT 7, THE ANAPHASE-PROMOTING COMPLEX |
21 | B | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
B: 1 - 84 (UniProt: Q9NYG5)
C, P: 1 - 597 (UniProt: Q9UJX2)
D: 6 - 121 (UniProt: P60006)
F, H: 1 - 824 (UniProt: P30260)
I: 1 - 808 (UniProt: Q9UJX5)
J: 1 - 620 (UniProt: Q13042)
K: 1 - 620 (UniProt: Q13042)
O: 1 - 755 (UniProt: Q9UJX4)
PDB | External Database | Details |
---|---|---|
Leu 13 | Thr 13 | conflict |
PDB | External Database | Details |
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Leu 161 | Lys 161 | conflict |
PDB | External Database | Details |
---|---|---|
Met 1 | - | expression tag |
Ser 2 | - | expression tag |
Thr 3 | - | expression tag |
Leu 4 | - | expression tag |
Tyr 5 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 475 | Ala 475 | conflict |
Ser 484 | Ala 484 | conflict |
PDB | External Database | Details |
---|---|---|
Asp 430 | Glu 430 | conflict |
PDB | External Database | Details |
---|---|---|
Asn 225 | Asp 225 | conflict |
Glu 228 | Gln 228 | conflict |
Lys 229 | Glu 229 | conflict |
Ala 347 | Glu 347 | conflict |
Ala 524 | Glu 524 | conflict |
PDB | External Database | Details |
---|---|---|
Glu 228 | Gln 228 | conflict |
Lys 229 | Glu 229 | conflict |
Lys 265 | Ala 265 | conflict |
PDB | External Database | Details |
---|---|---|
Ser 42 | Asn 42 | conflict |
Val 55 | Met 55 | conflict |
Gln 63 | Leu 63 | conflict |
Val 75 | Leu 75 | conflict |
Leu 79 | Tyr 79 | conflict |
Ser 164 | Asn 164 | conflict |
Asp 165 | Gly 165 | conflict |
Asn 167 | Lys 167 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 24 |
Total formula weight | 1166290.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 196.2 | |
All* | Total formula weight | 1166487.0 |