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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5A31

Structure of the human APC-Cdh1-Hsl1-UbcH10 complex.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 1polymer1441159616.51Pfam (PF12859)
Pfam (PF20518)
Pfam (PF21282)
Pfam (PF18122)
UniProt (by SIFTS) (Q9H1A4)		HOMO SAPIENS (HUMAN)APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR, TESTIS-SPECIFIC GENE 24 PROTEIN
2B
(B)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 11polymer849866.71UniProt (Q9NYG5)
Pfam (PF12861)		HOMO SAPIENS (HUMAN)APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA-ASSOC IATED RING FINGER PROTEIN
3C, P
(C, P)		CELL DIVISION CYCLE PROTEIN 23 HOMOLOGpolymer59768905.02UniProt (Q9UJX2)
Pfam (PF04049)		HOMO SAPIENS (HUMAN)ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME SUBUNIT 8, THE ANAPHASE-PROMOTING COMPLEX
4D
(D)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 15polymer12114302.71UniProt (P60006)
Pfam (PF15243)		HOMO SAPIENS (HUMAN)APC15
5E
(E)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 16polymer11011678.01UniProt (Q96DE5)
Pfam (PF17256)		HOMO SAPIENS (HUMAN)APC16, CYCLOSOME SUBUNIT 16
6F, H
(F, H)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 3polymer82492005.12UniProt (P30260)
Pfam (PF12895)
Pfam (PF00515)		HOMO SAPIENS (HUMAN)CELL DIVISION CYCLE PROTEIN 27 HOMOLOG, APC3, CDC27 HOMOLOG, CDC27HS, H-NUC
7G, V
(G, W)		ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26polymer859794.02UniProt (Q8NHZ8)
Pfam (PF10471)		HOMO SAPIENS (HUMAN)ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG
8I
(I)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 4polymer80892205.21UniProt (Q9UJX5)
Pfam (PF12894)
Pfam (PF12896)		HOMO SAPIENS (HUMAN)APC4, CYCLOSOME SUBUNIT 4
9J
(J)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 6polymer62071631.51UniProt (Q13042)
Pfam (PF12895)
Pfam (PF13424)		HOMO SAPIENS (HUMAN)CELL DIVISION CYCLE PROTEIN 16 HOMOLOG, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6
10K
(K)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 6polymer62071806.71UniProt (Q13042)
Pfam (PF12895)
Pfam (PF13424)		HOMO SAPIENS (HUMAN)CELL DIVISION CYCLE PROTEIN 16 HOMOLOG, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6
11L
(L)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 10polymer18521282.11UniProt (Q9UM13)
Pfam (PF03256)		HOMO SAPIENS (HUMAN)APC10, CYCLOSOME SUBUNIT 10
12M
(M)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 13polymer748528.31UniProt (Q2NKV2)
Pfam (PF05839)
UniProt (by SIFTS) (Q9BS18)		HOMO SAPIENS (HUMAN)APC13, CYCLOSOME SUBUNIT 13
13N
(N)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 2polymer70379116.51Pfam (PF00888)
Pfam (PF08672)
UniProt (by SIFTS) (Q9UJX6)		HOMO SAPIENS (HUMAN)APC2, CYCLOSOME SUBUNIT 2
14O
(O)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 5polymer75585087.51UniProt (Q9UJX4)
Pfam (PF21371)
Pfam (PF12862)		HOMO SAPIENS (HUMAN)APC5, CYCLOSOME SUBUNIT 5
15Q
(Q)		FUSION PROTEIN - UBIQUITIN-CONJUGATING ENZYME E2 C, UBIQUITIN-CONJUGATING ENZYME E2 Spolymer16217793.41Pfam (PF00179)
UniProt (by SIFTS) (O00762)		HOMO SAPIENS (HUMAN)(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME C, E2 UBIQUITIN-CONJUGATING ENZYME C, UBCH10, UBIQUITIN CARRIER PROTEIN C, UBIQUITIN-PROTEIN LIGASE C, UBIQUITIN CARRIER PROTEIN S, E2 UBIQUITIN-CONJUGATING ENZYME S, UBIQUITIN-CONJUGATING ENZYME E2-24 KDA, E2-EPF, UBIQUITIN-CONJUGATING ENZYME E2-EPF5, UBIQUITIN-PROTEIN LIGASE S
16R
(R)		THE ANAPHASE-PROMOTING COMPLEX CHAIN Rpolymer38642944.51Pfam (PF00400)
UniProt (by SIFTS) (P53197)		HOMO SAPIENS (HUMAN)
17S
(T)		THE ANAPHASE-PROMOTING COMPLEX CHAIN Tpolymer211876.31HOMO SAPIENS (HUMAN)
18T
(U)		THE ANAPHASE-PROMOTING COMPLEX CHAIN Upolymer242060.51HOMO SAPIENS (HUMAN)
19U
(V)		THE ANAPHASE-PROMOTING COMPLEX CHAIN Vpolymer131421.71HOMO SAPIENS (HUMAN)
20W, X
(X, Y)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 7polymer59966832.22UniProt (Q9UJX3)
Pfam (PF13181)
Pfam (PF13432)		HOMO SAPIENS (HUMAN)APC7, CYCLOSOME SUBUNIT 7, THE ANAPHASE-PROMOTING COMPLEX
21AA, Y, Z
(B)		ZINC IONnon-polymer65.43Chemie (ZN)
Sequence modifications
B: 1 - 84 (UniProt: Q9NYG5)
PDBExternal DatabaseDetails
Leu 13Thr 13conflict
C, P: 1 - 597 (UniProt: Q9UJX2)
PDBExternal DatabaseDetails
Leu 161Lys 161conflict
D: 6 - 121 (UniProt: P60006)
PDBExternal DatabaseDetails
Met 1-expression tag
Ser 2-expression tag
Thr 3-expression tag
Leu 4-expression tag
Tyr 5-expression tag
F, H: 1 - 824 (UniProt: P30260)
PDBExternal DatabaseDetails
Ser 475Ala 475conflict
Ser 484Ala 484conflict
I: 1 - 808 (UniProt: Q9UJX5)
PDBExternal DatabaseDetails
Asp 430Glu 430conflict
J: 1 - 620 (UniProt: Q13042)
PDBExternal DatabaseDetails
Asn 225Asp 225conflict
Glu 228Gln 228conflict
Lys 229Glu 229conflict
Ala 347Glu 347conflict
Ala 524Glu 524conflict
K: 1 - 620 (UniProt: Q13042)
PDBExternal DatabaseDetails
Glu 228Gln 228conflict
Lys 229Glu 229conflict
Lys 265Ala 265conflict
O: 1 - 755 (UniProt: Q9UJX4)
PDBExternal DatabaseDetails
Ser 42Asn 42conflict
Val 55Met 55conflict
Gln 63Leu 63conflict
Val 75Leu 75conflict
Leu 79Tyr 79conflict
Ser 164Asn 164conflict
Asp 165Gly 165conflict
Asn 167Lys 167conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains24
Total formula weight1166290.8
Non-Polymers*Number of molecules3
Total formula weight196.2
All*Total formula weight1166487.0
*Water molecules are not included.

246905

PDB entries from 2025-12-31

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