5A0B
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NEUTROPHIL ELASTASE | polymer | 218 | 23319.0 | 1 | UniProt (P08246) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | BONE MARROW SERINE PROTEASE, ELASTASE-2, HUMAN LEUKOCYTE EL ASTASE, HLE, MEDULLASIN, PMN ELASTASE, ELASTASE, HLE, MEDULIASIN, PMN ELASTASE |
| 2 | B, C (B, C) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 3 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 4 | E (A) | (4R)-4-(4-cyanophenyl)-6-methyl-2-oxidanylidene-3-[2-oxidanylidene-2-(4-propan-2-ylpiperazin-1-yl)ethyl]-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidine-5-carbonitrile | non-polymer | 550.6 | 1 | Chemie (JJX) | |||
| 5 | F (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | G (A) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23319.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 734.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 849.9 | |
| All* | Total formula weight | 24903.6 |
