5A0A
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | NEUTROPHIL ELASTASE | polymer | 218 | 23319.0 | 1 | UniProt (P08246) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | BONE MARROW SERINE PROTEASE, ELASTASE-2, HUMAN LEUKOCYTE EL ASTASE, HLE, MEDULLASIN, PMN ELASTASE, ELASTASE, HLE, MEDULIASIN, PMN ELASTASE |
| 2 | B, C (A, B) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 3 | D (E) | 5-[(6R)-5-ethanoyl-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile | non-polymer | 400.4 | 1 | Chemie (JJS) | |||
| 4 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | F (E) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 6 | G (E) | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23319.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 734.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 859.9 | |
| All* | Total formula weight | 24913.5 |
