4ZY0
X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10q
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Probable M17 family aminopeptidase | polymer | 522 | 57982.2 | 12 | UniProt (A0A024V0B1) Pfam (PF00883) | Plasmodium falciparum FcB1/Columbia | |
| 2 | CB, DA, DC, KB, KC... (F, C, I, G, J...) | N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(thiophen-3-yl)phenyl]ethyl}-2,2-dimethylpropanamide | non-polymer | 332.4 | 12 | Chemie (4TM) | |||
| 3 | AD, DB, EA, EB, EC... (L, F, C, I, G...) | ZINC ION | non-polymer | 65.4 | 24 | Chemie (ZN) | |||
| 4 | BD, FB, GA, GC, NB... (L, F, C, I, G...) | CARBONATE ION | non-polymer | 60.0 | 12 | Chemie (CO3) | |||
| 5 | CD, GB, HB, HC, IA... (L, F, I, C, J...) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 24 | Chemie (1PE) | |||
| 6 | AA, AB, AC, BA, BB... (B, E, H, L, F...) | SULFATE ION | non-polymer | 96.1 | 23 | Chemie (SO4) | |||
| 7 | HA, OB (C, G) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | FD, GD, HD, ID, JD... (A, B, C, D, E...) | water | water | 18.0 | 3291 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 82 - 603 (UniProt: A0A024V0B1)
| PDB | External Database | Details |
|---|---|---|
| Gln 152 | Asn 154 | engineered mutation |
| Gln 515 | Asn 517 | engineered mutation |
| Gln 546 | Asn 548 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 695786.8 | |
| Non-Polymers* | Number of molecules | 97 |
| Total formula weight | 14391.2 | |
| All* | Total formula weight | 710178.0 |
