4ZW6
X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | M1 family aminopeptidase | polymer | 890 | 103760.7 | 1 | UniProt (O96935) Pfam (PF17900) Pfam (PF01433) Pfam (PF11940) Pfam (PF17432) In PDB | Plasmodium falciparum | Pfa-M1 |
| 2 | A | tert-butyl {(1S)-2-(hydroxyamino)-1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-2-oxoethyl}carbamate | non-polymer | 346.4 | 1 | Chemie (4SY) | |||
| 3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | A | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 7 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 8 | water | water | 18.0 | 835 | Chemie (HOH) |
Sequence modifications
A: 195 - 1084 (UniProt: O96935)
| PDB | External Database | Details |
|---|---|---|
| Gln 213 | Asn 213 | engineered mutation |
| Gln 223 | Asn 223 | engineered mutation |
| Pro 378 | His 378 | engineered mutation |
| Gln 501 | Asn 501 | engineered mutation |
| Gln 745 | Asn 745 | engineered mutation |
| Gln 795 | Asn 795 | engineered mutation |
| Gln 1069 | Asn 1069 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 103760.7 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1263.5 | |
| All* | Total formula weight | 105024.2 |
