4ZTU
Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DNA polymerase subunit gamma-1 | polymer | 1222 | 138037.7 | 1 | UniProt (P54098) Pfam (PF18136) In PDB | Homo sapiens (Human) | Mitochondrial DNA polymerase catalytic subunit,PolG-alpha |
2 | B, C | DNA polymerase subunit gamma-2, mitochondrial | polymer | 472 | 53655.2 | 2 | UniProt (Q9UHN1) Pfam (PF03129) In PDB | Homo sapiens (Human) | DNA polymerase gamma accessory 55 kDa subunit,p55,Mitochondrial DNA polymerase accessory subunit,MtPolB,PolG-beta |
3 | T | DNA (25-MER) | polymer | 27 | 8235.3 | 1 | synthetic construct | ||
4 | P | DNA (5'-D(P*AP*AP*GP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3') | polymer | 24 | 7421.8 | 1 | synthetic construct | ||
5 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | A | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE | non-polymer | 451.2 | 1 | Chemie (DCT) |
Sequence modifications
A: 30 - 1239 (UniProt: P54098)
B, C: 26 - 485 (UniProt: Q9UHN1)
PDB | External Database | Details |
---|---|---|
Met 29 | - | expression tag |
Ala 198 | Asp 198 | engineered mutation |
Ala 200 | Glu 200 | engineered mutation |
Ala 1240 | - | expression tag |
Ala 1241 | - | expression tag |
Ala 1242 | - | expression tag |
Leu 1243 | - | expression tag |
Glu 1244 | - | expression tag |
His 1245 | - | expression tag |
His 1246 | - | expression tag |
His 1247 | - | expression tag |
His 1248 | - | expression tag |
His 1249 | - | expression tag |
His 1250 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 25 | - | expression tag |
Ala 486 | - | expression tag |
Ala 487 | - | expression tag |
Ala 488 | - | expression tag |
Leu 489 | - | expression tag |
Glu 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
His 493 | - | expression tag |
His 494 | - | expression tag |
His 495 | - | expression tag |
His 496 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 261005.1 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 499.8 | |
All* | Total formula weight | 261504.9 |