4ZTS
Human Aurora A catalytic domain bound to FK1142
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aurora kinase A | polymer | 285 | 32948.8 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | A | (2Z,5Z)-2-[(4-ethylphenyl)imino]-3-methyl-5-[(2-{[4-(1H-tetrazol-5-yl)phenyl]amino}pyridin-4-yl)methylidene]-1,3-thiazolidin-4-one | non-polymer | 482.6 | 1 | Chemie (4RK) | |||
| 3 | A | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 4 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| Ala 120 | - | expression tag |
| Met 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32948.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 600.7 | |
| All* | Total formula weight | 33549.5 |
