4ZTJ

Crystal Structure of the Prototype Foamy Virus Intasome with a 2-Pyridinone Aminal Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	PFV INTEGRASE	polymer	395	44456.7	2	UniProt (P14350) Pfam (PF17921) Pfam (PF00665) Pfam (PF18103)	Human spumaretrovirus (SFVcpz(hu))	Pr125Pol
2	C (C)	DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3')	polymer	19	5834.8	1		Human spumaretrovirus
3	D (D)	DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3')	polymer	17	5195.4	1		Human spumaretrovirus
4	E (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	F, G, N, P (A, B, C)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	H, I, O (A, B)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
7	J, K, M (A, B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
8	L (A)	(1R,2S,5R)-8'-(3-chloro-4-fluorobenzyl)-6'-hydroxy-1-(hydroxymethyl)-2'-methyl-9',10'-dihydro-2'H-spiro[bicyclo[3.1.0]hexane-2,3'-imidazo[5,1-a][2,6]naphthyridine]-1',5',7'(8'H)-trione	non-polymer		487.9	1	Chemie (4RT)
9	Q, R, S, T (A, B, C, D)	water	water		18.0	183	Chemie (HOH)

Sequence modifications

A, B: 1 - 392 (UniProt: P14350)

PDB	External Database	Details
Gly -2	-	expression tag
Pro -1	-	expression tag
Gly 0	-	expression tag
Ser 217	Gly 968	conflict
Gly 218	Ser 969	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	99943.6
Non-Polymers*	Number of molecules	12
	Total formula weight	1282.8
All*	Total formula weight	101226.4

*Water molecules are not included.