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4ZT4

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitorN-(3,5-dichlorobenzyl)-2,2-difluoro-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1708)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BMethionyl-tRNA synthetasepolymer54261434.72UniProt (Q38C91)
Pfam (PF09334)
Pfam (PF19303)
In PDB
Trypanosoma brucei brucei
2AMETHIONINEnon-polymer149.21Chemie (MET)
3ADIMETHYL SULFOXIDEnon-polymer78.13Chemie (DMS)
4BGLYCEROLnon-polymer92.11Chemie (GOL)
5BSULFATE IONnon-polymer96.11Chemie (SO4)
6BN-(3,5-dichlorobenzyl)-2,2-difluoro-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diaminenon-polymer386.21Chemie (4RO)
7waterwater18.0435Chemie (HOH)
Sequence modifications
A, B: 237 - 773 (UniProt: Q38C91)
PDBExternal DatabaseDetails
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Met 0-expression tag
Thr 309Ala 309conflict
Ala 452Lys 452engineered mutation
Arg 453Lys 453engineered mutation
Ala 454Glu 454engineered mutation
Val 499Ala 499conflict
Asn 503Ser 503conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight122869.4
Non-Polymers*Number of molecules7
Total formula weight958.0
All*Total formula weight123827.4
*Water molecules are not included.

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PDB entries from 2024-06-12

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