4ZQO
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor Q67
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase | polymer | 407 | 41642.6 | 1 | UniProt (P9WKI7) Pfam (PF00478) In PDB | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | IMPDH |
| 2 | A | INOSINIC ACID | non-polymer | 348.2 | 1 | Chemie (IMP) | |||
| 3 | A | N~2~-(2,3-dichlorophenyl)-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]-L-alaninamide | non-polymer | 427.3 | 1 | Chemie (Q67) | |||
| 4 | A | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | A | S-1,2-PROPANEDIOL | non-polymer | 76.1 | 1 | Chemie (PGO) | |||
| 7 | water | water | 18.0 | 188 | Chemie (HOH) |
Sequence modifications
A: 1 - 125 (UniProt: P9WKI7)
A: 253 - 529 (UniProt: P9WKI7)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 126 | - | linker |
| Gly 127 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41642.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 982.8 | |
| All* | Total formula weight | 42625.4 |
