4ZP4

Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Aryl hydrocarbon receptor nuclear translocator	polymer	384	43437.4	2	UniProt (P53762) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598)	Mus musculus (Mouse)	ARNT protein, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF1-beta
2	B, D (B, D)	Endothelial PAS domain-containing protein 1	polymer	360	41201.0	2	UniProt (P97481) Pfam (PF00989) Pfam (PF14598)	Mus musculus (Mouse)	EPAS-1, HIF-1-alpha-like factor, mHLF, HIF-related factor, HRF, Hypoxia-inducible factor 2-alpha, HIF2-alpha
3	E, F, G, H (A, B, C, D)	water	water		18.0	139	Chemie (HOH)

Sequence modifications

A, C: 82 - 464 (UniProt: P53762)

PDB	External Database	Details
Met 81	-	initiating methionine

B, D: 3 - 361 (UniProt: P97481)

PDB	External Database	Details
Met 2	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	169276.7
All*	Total formula weight	169276.7

*Water molecules are not included.