4ZME

Crystal Structure of the Alpha-kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Myosin heavy chain kinase A	polymer	307	34606.6	2	UniProt (P42527) Pfam (PF02816)	Dictyostelium discoideum (Slime mold)	MHCK-A
2	C, G (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, H (A, B)	ADENOSINE	non-polymer		267.2	2	Chemie (ADN)
4	E, F, I, J (A, B)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
5	K (B)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
6	L, M (A, B)	water	water		18.0	459	Chemie (HOH)

Sequence modifications

A, B: 552 - 841 (UniProt: P42527)

PDB	External Database	Details
Met 535	-	initiating methionine
Gly 536	-	expression tag
Gly 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
His 540	-	expression tag
His 541	-	expression tag
His 542	-	expression tag
His 543	-	expression tag
Gly 544	-	expression tag
Glu 545	-	expression tag
Asn 546	-	expression tag
Leu 547	-	expression tag
Tyr 548	-	expression tag
Phe 549	-	expression tag
Gln 550	-	expression tag
Gly 551	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69213.1
Non-Polymers*	Number of molecules	9
	Total formula weight	1195.4
All*	Total formula weight	70408.5

*Water molecules are not included.