4ZKS
The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-S195A) at pH7.4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | U | Urokinase-type plasminogen activator | polymer | 247 | 27828.7 | 1 | UniProt (P00749) Pfam (PF00089) In PDB | Homo sapiens (Human) | uPA |
| 2 | P | upain-1-W3A | polymer | 12 | 1233.4 | 1 | synthetic construct | ||
| 3 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
U: 16 - 244 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
| Ala 195 | Ser 376 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29062.1 | |
| All* | Total formula weight | 29062.1 |
