4ZKO
The crystal structure of upain-1-W3A in complex with uPA at pH7.4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (U) | Urokinase-type plasminogen activator | polymer | 247 | 27844.7 | 1 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (Human) | uPA |
| 2 | B (P) | N-terminal fragment of upain-1-W3A | polymer | 4 | 436.5 | 1 | synthetic construct | ||
| 3 | C (Q) | C-terminal fragment of upain-1-W3A | polymer | 8 | 961.1 | 1 | synthetic construct | ||
| 4 | D (U) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E (U) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 6 | F, G, H (U, P, Q) | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
U: 16 - 244 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 29242.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 378.4 | |
| All* | Total formula weight | 29620.7 |
