4ZI1
HUMAN ESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH KB095285 AND CIA12 COACTIVATOR PEPTIDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor beta | polymer | 249 | 28029.2 | 1 | UniProt (Q92731) Pfam (PF00104) | Homo sapiens (Human) | ER-beta,Nuclear receptor subfamily 3 group A member 2 |
| 2 | B (B) | Nuclear receptor coactivator 5 | polymer | 12 | 1286.4 | 1 | UniProt (Q9HCD5) | Homo sapiens | NCoA-5,Coactivator independent of AF-2,CIA |
| 3 | C (A) | 2-(4-hydroxyphenyl)-7-methyl-3-phenyl-1H-inden-5-ol | non-polymer | 314.4 | 1 | Chemie (KB0) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A: 262 - 509 (UniProt: Q92731)
B: 341 - 352 (UniProt: Q9HCD5)
| PDB | External Database | Details |
|---|---|---|
| Met 261 | - | initiating methionine |
| Asp 503 | Cys 503 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Glu 343 | Gln 343 | engineered mutation |
| Asp 347 | Asn 347 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29315.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 314.4 | |
| All* | Total formula weight | 29630.0 |
