4ZGK
Structure of Mdm2 with low molecular weight inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase Mdm2 | polymer | 98 | 11528.5 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | C, D (A, B) | (5R)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxyfuran-2(5H)-one | non-polymer | 498.8 | 2 | Chemie (4NX) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 114 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 114 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 23057.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 997.6 | |
| All* | Total formula weight | 24054.5 |
