4ZEG
Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein kinase TTK | polymer | 281 | 32459.3 | 1 | UniProt (P33981) Pfam (PF00069) | Homo sapiens (Human) | Phosphotyrosine picked threonine-protein kinase,PYT |
| 2 | B (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | C (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | D, E, F, G, H... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 5 | J (A) | N-cyclopropyl-2-methyl-4-(7-{[2-(morpholin-4-yl)ethyl]amino}-5-phenoxypyrazolo[1,5-a]pyrimidin-3-yl)benzamide | non-polymer | 512.6 | 1 | Chemie (052) | |||
| 6 | K (A) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32459.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1083.2 | |
| All* | Total formula weight | 33542.5 |
