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4Z9L

THE STRUCTURE OF JNK3 IN COMPLEX WITH AN IMIDAZOLE-PYRIMIDINE INHIBITOR

Replaces:  1PMQ
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Mitogen-activated protein kinase 10polymer36442001.61UniProt (P53779)
Pfam (PF00069)
Homo sapiens (Human)MAPK 10,MAP kinase p49 3F12,Stress-activated protein kinase 1b,SAPK1b,Stress-activated protein kinase JNK3,c-Jun N-terminal kinase 3
2B
(A)
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.21Chemie (ANP)
3C
(A)
CYCLOHEXYL-{4-[5-(3,4-DICHLOROPHENYL)-2-PIPERIDIN-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINEnon-polymer513.51Chemie (880)
4D, E, F
(A)
UNKNOWN ATOM OR IONnon-polymer3Chemie (UNX)
5G
(A)
waterwater18.067Chemie (HOH)
Sequence modifications
A: 40 - 401 (UniProt: P53779)
PDBExternal DatabaseDetails
Met 38-expression tag
Ala 39-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight42001.6
Non-Polymers*Number of molecules5
Total formula weight1019.7
All*Total formula weight43021.3
*Water molecules are not included.

227561

PDB entries from 2024-11-20

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