4Z77
Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | H-2 class I histocompatibility antigen, K-D alpha chain | polymer | 277 | 32353.0 | 2 | UniProt (P01902) Pfam (PF00129) Pfam (PF07654) In PDB | Mus musculus (House Mouse) | Leukocyte antigen heavy chain, H-2K(D) |
2 | B, E | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C, F | Insulin | polymer | 9 | 1052.3 | 2 | UniProt (P01308) In PDB | Homo sapiens (Human) | |
4 | E, A, B, D | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
5 | A, D | POLYETHYLENE GLYCOL (N=34) | non-polymer | 1529.8 | 3 | Chemie (15P) | |||
6 | D, E, A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
7 | D, E, A | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
8 | water | water | 18.0 | 411 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 275 (UniProt: P01902)
B, E: 1 - 99 (UniProt: P61769)
C, F: 1 - 9 (UniProt: P01308)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
His 114 | Gln 135 | conflict |
Pro 276 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Val 9 | Gly 47 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 90569.3 | |
Non-Polymers* | Number of molecules | 28 |
Total formula weight | 6555.3 | |
All* | Total formula weight | 97124.6 |