4Z33
Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Syntenin-1 | polymer | 166 | 18064.8 | 2 | UniProt (O00560) Pfam (PF00595) | Homo sapiens (Human) | Melanoma differentiation-associated protein 9,MDA-9,Pro-TGF-alpha cytoplasmic domain-interacting protein 18,TACIP18,Scaffold protein Pbp1,Syndecan-binding protein 1 |
| 2 | C, D (C, D) | LYS-GLY-GLU-THR-ALA-VAL | polymer | 6 | 604.7 | 2 | UniProt (by SIFTS) (O75084) | Homo sapiens | |
| 3 | E, I, J, K (A, B) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 4 | F, G (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | H (A) | D-MYO-INOSITOL-4,5-BISPHOSPHATE | non-polymer | 340.1 | 1 | Chemie (IP2) | |||
| 6 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A, B: 111 - 275 (UniProt: O00560)
| PDB | External Database | Details |
|---|---|---|
| Ser 110 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 37338.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 760.5 | |
| All* | Total formula weight | 38099.4 |
