4Z22
structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor DR718A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Plasmepsin-2 | polymer | 329 | 36909.6 | 2 | UniProt (W7FL77) Pfam (PF00026) UniProt (by SIFTS) (P46925) In PDB | Plasmodium falciparum | plasmepsin II |
| 2 | A, B | 2-amino-7-phenyl-3-{[(2R,5S)-5-phenyltetrahydrofuran-2-yl]methyl}quinazolin-4(3H)-one | non-polymer | 397.5 | 2 | Chemie (4KG) | |||
| 3 | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 329 (UniProt: W7FL77)
| PDB | External Database | Details |
|---|---|---|
| Ser 205 | Met 329 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73819.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 794.9 | |
| All* | Total formula weight | 74614.2 |
