4YZ9
Crystal Structure of human phosphorylated IRE1alpha in complex with a type III kinase inhibitor (GSK2850163A)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Serine/threonine-protein kinase/endoribonuclease IRE1 | polymer | 405 | 46610.6 | 3 | UniProt (O75460) Pfam (PF00069) Pfam (PF06479) | Homo sapiens (Human) | Endoplasmic reticulum-to-nucleus signaling 1,Inositol-requiring protein 1,hIRE1p,Ire1-alpha,IRE1a |
| 2 | D, E, F (A, B, C) | (5R)-2-(3,4-dichlorobenzyl)-N-(4-methylbenzyl)-2,7-diazaspiro[4.5]decane-7-carboxamide | non-polymer | 446.4 | 3 | Chemie (4K7) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 139831.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1339.2 | |
| All* | Total formula weight | 141170.9 |
