4YZ2

Crystal Structure of Streptococcus pneumoniae NanC, in complex with 2-deoxy-2,3-didehydro-N-acetylneuraminic acid.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sialidase NanC	polymer	677	75996.8	2	UniProt (Q97Q99) Pfam (PF02973) Pfam (PF02012) Pfam (PF13088) UniProt (by SIFTS) (A0A0H2UQE4)	Streptococcus pneumoniae
2	C, I (A, B)	2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID	non-polymer		291.3	2	Chemie (DAN)
3	D, E, F, G, H... (A, B)	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
4	O, P (A, B)	water	water		18.0	907	Chemie (HOH)

Sequence modifications

A, B: 84 - 740 (UniProt: Q97Q99)

PDB	External Database	Details
Met 64	-	initiating methionine
Ala 65	-	expression tag
His 66	-	expression tag
His 67	-	expression tag
His 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
Ser 72	-	expression tag
Ser 73	-	expression tag
Gly 74	-	expression tag
Leu 75	-	expression tag
Glu 76	-	expression tag
Val 77	-	expression tag
Leu 78	-	expression tag
Phe 79	-	expression tag
Gln 80	-	expression tag
Gly 81	-	expression tag
Pro 82	-	expression tag
Asn 83	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	151993.7
Non-Polymers*	Number of molecules	12
	Total formula weight	1543.1
All*	Total formula weight	153536.8

*Water molecules are not included.