4YUY

Crystal structure of Trypanosoma cruzi spermidine synthase in complex with isoquinolin-1-amine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Spermidine synthase, putative	polymer	304	34103.7	2	UniProt (Q4DA73) Pfam (PF17284) Pfam (PF01564)	Trypanosoma cruzi (strain CL Brener)
2	C, E (A, B)	5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE	non-polymer		356.4	2	Chemie (S4M)
3	D, F (A, B)	ISOQUINOLIN-1-AMINE	non-polymer		144.2	2	Chemie (1SQ)
4	G, H (A, B)	water	water		18.0	331	Chemie (HOH)

Sequence modifications

A, B: 1 - 296 (UniProt: Q4DA73)

PDB	External Database	Details
Met -7	-	initiating methionine
Ala -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68207.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1001.2
All*	Total formula weight	69208.7

*Water molecules are not included.