4YRL
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 4-(methylsulfanyl)aniline (Chem 262)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histidyl-tRNA synthetase | polymer | 456 | 51185.6 | 1 | UniProt (Q4DA54) Pfam (PF13393) Pfam (PF03129) | Trypanosoma cruzi (strain CL Brener) | |
| 2 | B (A) | HISTIDINE | non-polymer | 156.2 | 1 | Chemie (HIS) | |||
| 3 | C (A) | 4-(methylsulfanyl)aniline | non-polymer | 139.2 | 1 | Chemie (4JM) | |||
| 4 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | F, G, H (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | I (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 7 | J (A) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A: 45 - 478 (UniProt: Q4DA54)
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | initiating methionine |
| Ala -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| Met -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Thr -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Ala -8 | - | expression tag |
| Gln -7 | - | expression tag |
| Thr -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 51185.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 785.8 | |
| All* | Total formula weight | 51971.4 |
