4YR8

Crystal structure of JNK in complex with a regulator protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (E, A, C, F)	Mitogen-activated protein kinase 8	polymer	371	42830.5	4	UniProt (P45983) Pfam (PF00069)	Homo sapiens (Human)	MAPK 8,JNK-46,Stress-activated protein kinase 1c,SAPK1c,Stress-activated protein kinase JNK1,c-Jun N-terminal kinase 1
2	B, D, F, H (G, B, D, H)	Dual specificity protein phosphatase 16	polymer	167	18918.9	4	UniProt (Q9BY84) Pfam (PF00782)	Homo sapiens (Human)	Mitogen-activated protein kinase phosphatase 7,MKP-7
3	I, J, K, L (G, B, D, H)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
4	M, N, O, P, Q... (E, G, A, B, C...)	water	water		18.0	356	Chemie (HOH)

Sequence modifications

E, A, C, F: 1 - 363 (UniProt: P45983)

PDB	External Database	Details
Leu 364	-	expression tag
Glu 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
His 369	-	expression tag
His 370	-	expression tag
His 371	-	expression tag

G, B, D, H: 156 - 301 (UniProt: Q9BY84)

PDB	External Database	Details
Met 135	-	expression tag
Gly 136	-	expression tag
Ser 137	-	expression tag
Ser 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
Ser 145	-	expression tag
Ser 146	-	expression tag
Gly 147	-	expression tag
Leu 148	-	expression tag
Val 149	-	expression tag
Pro 150	-	expression tag
Arg 151	-	expression tag
Gly 152	-	expression tag
Ser 153	-	expression tag
His 154	-	expression tag
Met 155	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	246997.5
Non-Polymers*	Number of molecules	4
	Total formula weight	141.8
All*	Total formula weight	247139.3

*Water molecules are not included.