4YQD

Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	tRNA (guanine-N(1)-)-methyltransferase	polymer	266	29750.0	1	UniProt (P43912) Pfam (PF01746) In PDB	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	M1G-methyltransferase,tRNA [GM37] methyltransferase
2	A	6-{[(1-{2-[(3-methylbenzoyl)amino]ethyl}cyclohexyl)methyl]amino}pyridine-3-carboxamide	non-polymer		394.5	1	Chemie (4GZ)
3		water	water		18.0	208	Chemie (HOH)

Sequence modifications

A: 1 - 246 (UniProt: P43912)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29750.0
Non-Polymers*	Number of molecules	1
	Total formula weight	394.5
All*	Total formula weight	30144.5

*Water molecules are not included.