4YNK

Crystal structure of vitamin D receptor ligand binding domain complexed with a 19-norvitamin D compound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Vitamin D3 receptor,Vitamin D3 receptor	polymer	271	30595.0	1	UniProt (P13053) Pfam (PF00104) In PDB	Rattus norvegicus (Rat)	VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1,VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1
2	C	Coactivator peptide drip from cDNA FLJ50196, highly similar to Peroxisome proliferator-activated receptor-binding protein	polymer	13	1570.9	1	UniProt (by SIFTS) (Q15648) In PDB	Homo sapiens
3	A	(1R,3R,7E,17beta)-17-{(5S)-5-hydroxy-5-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-1-yl]penta-1,3-diyn-1-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol	non-polymer		500.7	1	Chemie (YW2)
4		water	water		18.0	47	Chemie (HOH)

Sequence modifications

A: 116 - 211 (UniProt: P13053)

PDB	External Database	Details
Gly 106	-	expression tag
Ser 107	-	expression tag
His 108	-	expression tag
Met 109	-	expression tag
Gly 110	-	expression tag
Ser 111	-	expression tag
Pro 112	-	expression tag
Asn 113	-	expression tag
Ser 114	-	expression tag
Pro 115	-	expression tag

A: 212 - 423 (UniProt: P13053)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32165.9
Non-Polymers*	Number of molecules	1
	Total formula weight	500.7
All*	Total formula weight	32666.6

*Water molecules are not included.