4YLQ
Crystal Structure of a FVIIa-Trypsin Chimera (FT) in Complex with Soluble Tissue Factor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Coagulation factor VII | polymer | 152 | 17487.1 | 1 | UniProt (P08709) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (Human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA |
| 2 | B (H) | Coagulation factor VII | polymer | 249 | 27508.6 | 1 | UniProt (P08709) Pfam (PF00089) | Homo sapiens (Human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA |
| 3 | C (T) | Tissue factor | polymer | 219 | 24826.5 | 1 | UniProt (P13726) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (Human) | TF,Coagulation factor III,Thromboplastin |
| 4 | D (A) | alpha-D-xylopyranose-(1-3)-alpha-D-xylopyranose-(1-3)-beta-D-glucopyranose | branched | 444.4 | 1 | In PDB GlyTouCan (G41179DF) | |||
| 5 | E, F, G, H, I... (L, H) | CALCIUM ION | non-polymer | 40.1 | 9 | Chemie (CA) | |||
| 6 | M (L) | alpha-L-fucopyranose | non-polymer | 164.2 | 1 | Chemie (FUC) | |||
| 7 | AA, BA, CA, DA, EA... (T, L, H) | TETRAMETHYLAMMONIUM ION | non-polymer | 74.1 | 22 | Chemie (TMA) | |||
| 8 | O (H) | N-acetyl-D-phenylalanyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide | non-polymer | 546.1 | 1 | Chemie (0Z7) | Homo sapiens (Human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA | |
| 9 | W (H) | N-PROPANOL | non-polymer | 60.1 | 1 | Chemie (POL) | |||
| 10 | MA, NA, OA (L, H, T) | water | water | 18.0 | 575 | Chemie (HOH) |
Sequence modifications
H: 16 - 257 (UniProt: P08709)
| PDB | External Database | Details |
|---|---|---|
| - | Leu 371 | deletion |
| - | Gln 372 | deletion |
| - | Gln 373 | deletion |
| - | Ser 374 | deletion |
| - | Arg 375 | deletion |
| Glu 169 | Lys 376 | engineered mutation |
| Ala 170 | Val 377 | engineered mutation |
| Ser 171 | Gly 378 | engineered mutation |
| Phe 172 | Asp 379 | engineered mutation |
| Pro 173 | Ser 380 | engineered mutation |
| Gly 174 | Pro 381 | engineered mutation |
| Lys 175 | Asn 382 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69822.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 444.4 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 2762.2 | |
| All* | Total formula weight | 73028.8 |
