4YKN

Pi3K alpha lipid kinase with Active Site Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphatidylinositol 3-kinase regulatory subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform fusion protein	polymer	1383	161845.3	1	UniProt (P27986) UniProt (P42336) Pfam (PF00017) Pfam (PF16454) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB	Homo sapiens (Human)	PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha,PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA
2	A	3-(6-methoxypyridin-3-yl)-5-[({4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}amino)methyl]benzoic acid	non-polymer		511.6	3	Chemie (4EL)
3		water	water		18.0	94	Chemie (HOH)

Sequence modifications

A: 318 - 990 (UniProt: P27986)

PDB	External Database	Details
Met 311	-	initiating methionine
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
Gly 991	-	linker
Ser 992	-	linker
Pro 993	-	linker
Gly 994	-	linker
Ile 995	-	linker
Ser 996	-	linker
Gly 997	-	linker
Gly 998	-	linker
Gly 999	-	linker
Gly 1000	-	linker
Gly 1001	-	linker

A: 1002 - 2068 (UniProt: P42336)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	161845.3
Non-Polymers*	Number of molecules	3
	Total formula weight	1534.7
All*	Total formula weight	163380.0

*Water molecules are not included.