4YK5
Crystal Structures of mPGES-1 Inhibitor Complexes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prostaglandin E synthase | polymer | 154 | 17249.4 | 1 | UniProt (O14684) Pfam (PF01124) | Homo sapiens (Human) | Microsomal glutathione S-transferase 1-like 1,MGST1-L1,Microsomal prostaglandin E synthase 1,MPGES-1,p53-induced gene 12 protein |
| 2 | B (A) | 3-[1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbiphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid | non-polymer | 540.1 | 1 | Chemie (4DV) | |||
| 3 | C (A) | 2-(2-METHOXYETHOXY)ETHANOL | non-polymer | 120.1 | 1 | Chemie (PG0) | |||
| 4 | D (A) | GLUTATHIONE | non-polymer | 307.3 | 1 | Chemie (GSH) | |||
| 5 | E (A) | hexyl beta-D-glucopyranoside | non-polymer | 264.3 | 1 | Chemie (JZR) | |||
| 6 | F (A) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 1 | Chemie (BOG) | |||
| 7 | G (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 8 | H (A) | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A: 2 - 152 (UniProt: O14684)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17249.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1718.4 | |
| All* | Total formula weight | 18967.9 |
