4YJ5
Crystal structure of PKM2 mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase PKM | polymer | 518 | 56682.3 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (Human) | Cytosolic thyroid hormone-binding protein,CTHBP,Opa-interacting protein 3,OIP-3,Pyruvate kinase 2/3,Pyruvate kinase muscle isozyme,Thyroid hormone-binding protein 1,THBP1,Tumor M2-PK,p58 |
| 2 | E, H, L, P (A, B, C, D) | PYRUVIC ACID | non-polymer | 88.1 | 4 | Chemie (PYR) PubChem (1060) | |||
| 3 | F, I, M, Q (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 4 | G, J, N, R (A, B, C, D) | SERINE | non-polymer | 105.1 | 4 | Chemie (SER) PubChem (617) PubChem (5951) PubChem (71077) | |||
| 5 | K, O, S (B, C, D) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 3 | Chemie (FBP) PubChem (718) PubChem (10267) PubChem (172313) PubChem (440117) PubChem (5702629) PubChem (12800340) PubChem (16219368) PubChem (24802138) PubChem (46937007) PubChem (445557) PubChem (92209487) PubChem (124383956) PubChem (124540446) PubChem (135053794) PubChem (89534552) PubChem (92209485) PubChem (92209486) PubChem (123134048) PubChem (124202619) PubChem (124427861) PubChem (124524513) PubChem (124604817) PubChem (130233858) PubChem (133126640) PubChem (135055131) PubChem (140434362) PubChem (146159004) PubChem (160510795) | |||
| 6 | T, U, V, W (A, B, C, D) | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 14 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Tyr 391 | His 391 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 226729.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1890.2 | |
| All* | Total formula weight | 228619.5 |
