4YJ5
Crystal structure of PKM2 mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase PKM | polymer | 518 | 56682.3 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (Human) | Cytosolic thyroid hormone-binding protein,CTHBP,Opa-interacting protein 3,OIP-3,Pyruvate kinase 2/3,Pyruvate kinase muscle isozyme,Thyroid hormone-binding protein 1,THBP1,Tumor M2-PK,p58 |
| 2 | E, H, L, P (A, B, C, D) | PYRUVIC ACID | non-polymer | 88.1 | 4 | Chemie (PYR) | |||
| 3 | F, I, M, Q (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G, J, N, R (A, B, C, D) | SERINE | non-polymer | 105.1 | 4 | Chemie (SER) | |||
| 5 | K, O, S (B, C, D) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 3 | Chemie (FBP) | |||
| 6 | T, U, V, W (A, B, C, D) | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 14 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Tyr 391 | His 391 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 226729.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1890.2 | |
| All* | Total formula weight | 228619.5 |
