4YHT
bRaf complexed with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase B-raf | polymer | 272 | 30978.7 | 2 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | C, E (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D, F (A, B) | 3-[(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-(morpholin-4-yl)benzenesulfonamide | non-polymer | 422.9 | 2 | Chemie (4EF) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A, B: 448 - 719 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Thr 542 | Ile 543 | engineered mutation |
| Asn 543 | Ile 544 | engineered mutation |
| Thr 550 | Ile 551 | engineered mutation |
| Thr 705 | Leu 706 | engineered mutation |
| Thr 715 | Leu 716 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61957.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1030.0 | |
| All* | Total formula weight | 62987.4 |
